Xiao Xu

Selenoprotein P Deficiency Drives Hepatocellular Carcinoma Progression via Induction of Neutrophil Senescence and Immunosuppressive Microenvironment

This study shows that selenoprotein P deficiency promotes hepatocellular carcinoma by inducing neutrophil senescence and an immunosuppressive microenvironment.

Extracellular vesicle-derived miRNA-mediated cell-cell communication inference for single-cell transcriptomic data with miRTalk

miRTalk infers EV-derived miRNA-mediated cell-cell communication from scRNA-seq data, showing high accuracy in simulated and real datasets.

Cholesterol binding to VCAM-1 promotes vascular inflammation

The paper identifies cholesterol binding to VCAM-1 as a mechanism promoting vascular inflammation by stabilizing VCAM-1 and enhancing immune cell recruitment.

Knowledge-graph-based cell-cell communication inference for spatially resolved transcriptomic data with SpaTalk

SpaTalk infers cell-cell communication from spatial transcriptomic data using a knowledge graph and graph network, outperforming existing methods on public datasets and revealing insights into tissue communication mechanisms.

Single-cell analysis reveals a pathogenic cellular module associated with early allograft dysfunction after liver transplantation

The paper constructs a single-cell transcriptomic atlas of transplanted livers and identifies an EAD-associated pathogenic cellular module.