Synthetic BiologyFrontiers in Bioengineering and BiotechnologyPeer-reviewed
An Enhanced Split Intein-Mediated Ligation (SIML) Platform for Rapid Discovery and Functional Screening of Circular Bacteriocins
Ester Sevillano, Mohamed El Bakkoury, Irene Lafuente…·Juan Borrero
The paper introduces an enhanced SIML platform for synthesizing and screening circular bacteriocins, showing that intein choice and cyclization sites affect antimicrobial activity.
DOI 10.3389/fbioe.2026.1950086