Sarah E. Pinder

CNN patch classifiers trained only on normal breast H&E slides label epithelium, stroma and adipocytes with AUCs of 0.98–1.00 on three external cohorts and feed a lobule-detection pipeline.

The paper introduces SMART, a spatio-molecular atlas of TNBC response trajectories, revealing distinct epithelial archetypes and tumor-immune microenvironments associated with treatment response and prognosis.

The paper uses genomic profiling to show that some invasive breast cancers are clonally unrelated to their preceding DCIS, suggesting DCIS may act as both a precursor and independent risk factor.