Anita E. Grigoriadis

The paper identifies a 6-gene stromal signature, Stroma6, that predicts early relapse in low-risk and chemoresistant breast cancer patients, independent of Oncotype DX results.

The paper identifies extrafollicular plasma cells as an antibody-independent checkpoint that inhibits dendritic cell-T-cell priming in tumor-draining lymph nodes, leading to poor prognosis and immune-checkpoint resistance.

CNN patch classifiers trained only on normal breast H&E slides label epithelium, stroma and adipocytes with AUCs of 0.98–1.00 on three external cohorts and feed a lobule-detection pipeline.

This study identifies lactate as a tumor-secreted metabolite that inhibits B cell chemotaxis and TLS formation in TNBC by disrupting mitochondrial metabolism.

The paper introduces SMART, a spatio-molecular atlas of TNBC response trajectories, revealing distinct epithelial archetypes and tumor-immune microenvironments associated with treatment response and prognosis.

NoButter reduces transcript dispersion in CosMx Spatial Molecular Imaging data by excluding high-dispersion Z-slices, improving data quality.

The paper uses genomic profiling to show that some invasive breast cancers are clonally unrelated to their preceding DCIS, suggesting DCIS may act as both a precursor and independent risk factor.