Adrian Straub

The study identifies over 27,000 unique epitope-reactive TCRs from immunized mice, showing that TCR diversity is not constrained by germline VJ combinations but by combinatorial pairing of segments and CDR3 sequences.

The paper develops a mass cytometry method to track T cell receptor repertoires and differentiation states during infection and immunotherapy, showing how antigen recognition influences T cell responses.

P-TEAM predicts the effect of epitope mutations on T cell functionality using a Random Forest model trained on murine and human TCR-epitope interactions.