Dirk Hans Busch

The study identifies over 27,000 unique epitope-reactive TCRs from immunized mice, showing that TCR diversity is not constrained by germline VJ combinations but by combinatorial pairing of segments and CDR3 sequences.

This study identifies SATB1 as a regulator of JAK-STAT signaling and cytokines in human Treg and Tconv cells, showing its potential as a target for CAR T cell therapy.

The paper shows that Treg cells use IFNγ and IL-10 to promote intestinal stem cell growth and repair after injury.

The paper investigates how spatial separation of antigens affects cytotoxicity in CAR-TCR cells by analyzing clonotype dynamics and functional TCR contributions.

The paper analyzes T cell responses to mRNA vaccination, finding that polyclonality and high, but not maximum, antigen receptor avidity correlate with response quality.

This study shows that IBD susceptibility increases the risk of ATF6-driven tumorigenesis in a murine model.

This paper demonstrates the use of generative AI to design de novo binders for CAR-T cells targeting cancer antigens, showing comparable efficacy to traditional scFv-based CAR-T cells.

The paper develops a mass cytometry method to track T cell receptor repertoires and differentiation states during infection and immunotherapy, showing how antigen recognition influences T cell responses.

This study shows that pentanoate, a microbial postbiotic, is metabolized to citrate, which influences T cell differentiation and anti-cancer CAR T cell efficacy through epigenetic mechanisms.

The paper uses live-cell imaging to study TCR:pMHC interactions in anti-viral and autoimmunity settings, revealing differences in synaptic engagement, CD8 co-engagement, and signaling efficiency that define central tolerance boundaries.

P-TEAM predicts the effect of epitope mutations on T cell functionality using a Random Forest model trained on murine and human TCR-epitope interactions.