Jesse Garcia Castillo

This study shows that Listeria monocytogenes evades MAIT cells by lacking riboflavin biosynthesis, and engineered strains that produce riboflavin activate MAIT cells, offering therapeutic potential against infections and cancer.

This study shows targeting FSP1 in regulatory T cells disrupts their immunosuppression, enhancing anti-tumor immunity without causing autoimmunity.

This study shows that aging reduces 2,6-linked sialic acids on T cells, leading to exhaustion and impaired immune function.

This study shows that TLR2 signaling in innate immune cells within tumors reduces Treg stability, enhancing cancer immunotherapy by improving CD8+ T cell function.

The paper develops a mass cytometry method to track T cell receptor repertoires and differentiation states during infection and immunotherapy, showing how antigen recognition influences T cell responses.

This study investigates how different routes of Listeria monocytogenes administration affect tumor growth in mice, finding that IV followed by IT administration controls tumor growth through anti-Lm CD8 T cells.

This study identifies FGF5 signaling as a key driver in SHH subgroup infantile medulloblastoma, showing its upregulation and therapeutic potential through FGFR inhibition.

This study shows that Sufu regulates Shh signaling to control the expansion and quiescence of neural stem cells in the developing dentate gyrus.

This study shows that Sufu deletion in neural progenitors causes increased proliferation and reduced survival of stem/precursor cells in the dorsal V-SVZ via a Gli3-dependent mechanism.