Ville Paakinaho

The paper identifies p63 as a molecular switch that determines the glucocorticoid receptor's role as a tumor suppressor or oncogene in prostate cancer.

The paper shows that direct chromatin crosstalk between androgen receptor and glucocorticoid receptor in prostate cancer leads to distinct transcriptional responses associated with improved patient survival.

The paper identifies chromatin pre-accessibility and FOXA1-mediated repression as key regulators of GR action in prostate cancer, offering new strategies to combat antiandrogen resistance.