Einari A. Niskanen

This study develops hybrid lipid-VLPSi nanoparticles to enhance mRNA delivery, finding that amino-modified VLPSi significantly improves transfection efficiency compared to conventional LNPs.

The paper shows that direct chromatin crosstalk between androgen receptor and glucocorticoid receptor in prostate cancer leads to distinct transcriptional responses associated with improved patient survival.

KMAP is a method for visualizing DNA sequences by projecting kmers into 2D space, showing it can detect patterns comparable to MEME and find biologically relevant interactions in ChIP-seq and gene editing data.

The paper identifies chromatin pre-accessibility and FOXA1-mediated repression as key regulators of GR action in prostate cancer, offering new strategies to combat antiandrogen resistance.