Mark Robert Segal

The paper identifies shared mechanisms of HBsAg seroclearance using a mouse model and longitudinal PBMCs from CHB patients, showing CD4+ T cell activation is essential for clinical cure.

The paper improves a method for inferring 3D chromatin structure from Hi-C data by introducing a new framework that addresses initialization issues and extends distribution models for contact counts.

The paper refines the multiMDS approach to identify 3D chromatin relocalization regions using PRIM, avoiding 1D limitations and comparing four cell types.

The paper identifies soluble TNF receptor 1 (sTNFR1) as a therapeutic target for spinal cord injury using multi-dimensional analysis of preclinical data.

This paper introduces a principal curve method for inferring 3D chromatin architecture from Hi-C data, showing its utility and reproducibility in reconstructing chromosome structures.