Clinical cure of chronic hepatitis B is dependent on activation and perpetuation of robust CD4+ T cell responses
Jillian M. Jespersen, Lia Avanesyan, Jean Publicover…·Jody L. Baron
The paper identifies shared mechanisms of HBsAg seroclearance using a mouse model and longitudinal PBMCs from CHB patients, showing CD4+ T cell activation is essential for clinical cure.