Author

Nandish Khanra

Memorial Sloan Kettering Cancer CenterORCID 0000-0003-4217-1273Unclaimed ORCID profile · follow to get notified of new preprints

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Biochemistry· 1

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Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

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Bryce D. DelgadoiD· 1 shared Chongyuan WangiD· 1 shared Stephen Barstow LongiD· 1 shared

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Bryce D. DelgadoORCID

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1 paper

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BiochemistryProceedings of the National Academy of SciencesPeer-reviewedMay 9, 2025

Structure of the human TWIK-2 potassium channel and its inhibition by pimozide

Nandish Khanra, Chongyuan Wang, Bryce D. Delgado, Stephen Barstow Long

This paper reports the cryo-EM structure of the human TWIK-2 potassium channel and shows that pimozide inhibits it by displacing acyl chains and blocking ion conduction.

11 citations

humanstructural biology

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