Author

Stephen Barstow Long

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-8144-1398Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:structural biology· 2 Research Focus:cell type annotation· 1 Organism:chicken / avian· 1 Assay:electrophysiology· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Bryce D. DelgadoiD· 1 shared Chongyuan WangiD· 1 shared Nandish KhanraiD· 1 shared Stephanie W. TamiD· 1 shared Swati PantiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 4 mutual co-author links

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1 shared paperBiochemistry

Bryce D. DelgadoORCID

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2 papers

Recent·Most cited

BiochemistryProceedings of the National Academy of SciencesPeer-reviewedMay 9, 2025

Structure of the human TWIK-2 potassium channel and its inhibition by pimozide

Nandish Khanra, Chongyuan Wang, Bryce D. Delgado, Stephen Barstow Long

This paper reports the cryo-EM structure of the human TWIK-2 potassium channel and shows that pimozide inhibits it by displacing acyl chains and blocking ion conduction.

11 citations

humanstructural biology

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BiochemistryProceedings of the National Academy of SciencesPeer-reviewedApr 18, 2025

The pentameric chloride channel BEST1 is activated by extracellular GABA

Swati Pant, Stephanie W. Tam, Stephen Barstow Long

This study shows that BEST1, a chloride channel, is directly activated by extracellular GABA, with structural and functional evidence revealing the mechanism of GABA-induced channel opening.

7 citations

humanchicken / avian

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