Jack D. Barchas

Exomes of 24,248 schizophrenia cases and 97,322 controls implicate ultra-rare damaging variants in 10 genes, including GRIN2A and GRIA3, with odds ratios of 3 to 50.

The paper examines common genetic variants' contribution to bipolar disorder risk in multiplex families and finds higher polygenic risk scores in affected individuals compared to controls and unaffected family members.

This study identifies 73 genome-wide significant loci for mood disorders, revealing shared and distinct genetic factors between major depressive disorder and bipolar disorder.

This study identifies 30 genome-wide significant loci associated with bipolar disorder, including novel genes involved in ion channels, neurotransmitters, and synaptic components.

The paper predicts cell type composition in human brain transcriptomic datasets and shows how age, death manner, dissection, and psychiatric diagnosis affect cell type ratios.

This study identifies 114 genome-wide significant loci for schizophrenia and bipolar disorder, with specific subphenotype associations and four genes distinguishing the disorders.

The paper compares transcriptomes and metabolomes of postmortem brain samples from schizophrenia, bipolar disorder, major depressive disorder, and controls to identify molecular differences and potential therapeutic targets.