Huda Akil

The paper uses in vivo metabolomics to identify neurochemical differences between temperaments linked to SUD vulnerability and shows how cocaine exposure alters these states.

This paper performs two meta-analyses of transcriptional data from rodent brain regions to identify shared gene expression changes across antidepressant categories.

This paper performs a meta-analysis of antipsychotic effects on frontal cortex transcriptomes in rodents and non-human primates, identifying 63 differentially expressed genes.

The paper identifies genetic loci associated with anxiety-like and nociceptive traits in outbred Sprague-Dawley rats using genome-wide association analysis.

This study compares how cocaine and heroin self-administration is acquired in rats with internalizing vs. externalizing temperament, finding drug-specific and sex-dependent differences.

The paper improves mouse and rat genome annotation by identifying unannotated genes and transcripts using a new pipeline applied to RNA-seq data.

This paper identifies 133 consistently differentially expressed genes in the prefrontal cortex of chronically stressed mice across multiple stress paradigms and finds convergence with human psychiatric disorder gene expression patterns.

This study performs a meta-analysis of rodent sleep deprivation transcriptome data to identify consistently differentially expressed genes across multiple studies.

This paper performs a meta-analysis of three mouse datasets to identify stress-related gene expression changes in whole blood and links them to immune dysregulation and cellular aging.

This paper performs a meta-analysis of gene expression data from five datasets to identify long-term effects of early life stress on the prefrontal cortex, finding consistent downregulation of myelin-related genes and upregulation of genes related to Major Depressive Disorder.

The paper identifies DNA variants with allele bias in TF binding across human brain regions, linking them to eQTLs and providing insights into gene regulation effects of common and rare variation.

The paper introduces Brain.GMT, a curated database of brain-related gene sets to improve interpretation of neuroscience studies by addressing the limitations of traditional gene ontology databases.

The paper generates a multi-omic resource of TF binding maps in human brain tissues and links TF activities to neuropsychiatric disorder risk variants.

This study shows that adolescent environmental enrichment improves social resilience and alters gene expression in genetically anxious rats, with differential effects on behavior and stress response.

The paper presents an improved rat reference genome, mRatBN7.2, which enhances genomic, transcriptomic, and proteomics data mapping and identifies millions of genetic variations across rat strains.

The paper shows that high emotional reactivity in mice is linked to a distinct hippocampal-amygdala circuit influenced by glucocorticoid receptor overexpression.

The paper shows that inhibiting VTA dopamine neurons during reward cue presentation prevents sign-tracking behavior, confirming dopamine's role in encoding incentive value.

The study identifies brain regions whose activation during initial social stress predicts future resilience or susceptibility in mice using the CSDS model.

This study introduces a CRISPR-based Oprm1-Cre knock-in rat to investigate the role of nucleus accumbens MOR-expressing cells in heroin self-administration, finding sex-specific effects on acquisition and effort.

This study identifies genetic loci associated with exploratory locomotion and anxiety-like traits in a selectively bred rat model using a genome-wide association approach.

This study shows that GR overexpression in forebrain neurons alters hippocampal encoding of environmental experiences in mice, increasing activity and sensitivity to emotionally salient behaviors.

The paper identifies gene expression patterns in the hippocampus of rats that predict internalizing and externalizing behaviors, linking them to genetic variation and biological processes.

This study shows adolescent cocaine exposure affects psychomotor sensitization and epigenetic profiles differently in genetically distinct rat strains, linking these changes to addiction vulnerability.

Exomes of 24,248 schizophrenia cases and 97,322 controls implicate ultra-rare damaging variants in 10 genes, including GRIN2A and GRIA3, with odds ratios of 3 to 50.

The paper investigates how microglia morphology differs between rat lines with distinct emotional temperaments and links these differences to baseline microglial reactivity.

The paper characterizes behavioral, physiological, and neuroendocrine profiles of mice before, during, and after chronic social defeat stress, finding that early coping strategies better predict resilience or susceptibility than traditional behavioral read-outs.

The paper identifies convergent genomic modules in stress models of mice, revealing shared biological functions across different stress paradigms.

The paper investigates threat learning in anxiety-like rats, showing that maternal presence and FGF2 administration can suppress early conditioned freezing, though not corticosterone levels.

The paper optimizes in situ hybridization chain reaction in fresh-frozen brain tissues and evaluates its performance with clearing methods, finding iDISCO+ provides better labeling uniformity and imaging depth.