Anton Schulmann

Transcriptomic signatures of nine high-risk neuropsychiatric copy number variants in human brain cells

The paper analyzes transcriptomic differences in human brain cells with nine high-risk neuropsychiatric CNVs compared to non-carriers, finding widespread gene expression disruptions and shared functional pathways.

A conserved cell-type gradient across the human mediodorsal and paraventricular thalamus

The paper identifies a conserved excitatory neuron gradient in human mediodorsal thalamus using single-nucleus and spatial transcriptomics, linking it to psychiatric disorder risk.

Deep transcriptome sequencing of subgenual anterior cingulate cortex reveals disorder-specific expression changes in major psychiatric disorders

The paper uses deep RNA sequencing to compare gene expression in the subgenual anterior cingulate cortex across major psychiatric disorders and controls, finding disorder-specific expression changes and genetic associations.

Cortical RORβ is required for layer 4 transcriptional identity and barrel integrity.

This study shows RORβ is essential for layer 4 transcriptional identity and barrel structure in the cortex, with loss of RORβ disrupting gene expression, chromatin accessibility, and thalamocortical afferent organization.

Super-resolution Imaging Reveals 3D Structure and Organizing Mechanism of Accessible Chromatin

This study uses super-resolution imaging to reveal the 3D structure and organizing mechanism of accessible chromatin domains.

INFERENCE OF CELL TYPE COMPOSITION FROM HUMAN BRAIN TRANSCRIPTOMIC DATASETS ILLUMINATES THE EFFECTS OF AGE, MANNER OF DEATH, DISSECTION, AND PSYCHIATRIC DIAGNOSIS

The paper predicts cell type composition in human brain transcriptomic datasets and shows how age, death manner, dissection, and psychiatric diagnosis affect cell type ratios.

A single spectrum of neuronal identities across thalamus

The paper constructs a transcriptomic atlas of the thalamus, revealing a single spectrum of neuronal identities that serve as molecularly-defined filters for cortical modalities.

The Transcriptional Logic of Mammalian Neuronal Diversity

The paper identifies homeobox transcription factors as key drivers of neuronal diversity through improved expression metrics and links long genes to regulatory elements and mobile elements.