Megan Hastings Hagenauer

The Converging Effects of Different Categories of Antidepressants on the Brain: A Systematic Meta-Analysis of Public Transcriptional Profiling Data from the Hippocampus and Cortex

This paper performs two meta-analyses of transcriptional data from rodent brain regions to identify shared gene expression changes across antidepressant categories.

A Meta-Analysis of the Converging Effects of Different Classes of Antipsychotics on the Frontal Cortex Transcriptome in Laboratory Rodents and Non-Human Primates

This paper performs a meta-analysis of antipsychotic effects on frontal cortex transcriptomes in rodents and non-human primates, identifying 63 differentially expressed genes.

Significantly Improved Mouse and Rat Genome Annotation Using Sequence Read Archive RNA-seq Data

The paper improves mouse and rat genome annotation by identifying unannotated genes and transcripts using a new pipeline applied to RNA-seq data.

A Meta-Analysis of the Effects of Chronic Stress on the Prefrontal Transcriptome in Animal Models and Convergence with Existing Human Data

This paper identifies 133 consistently differentially expressed genes in the prefrontal cortex of chronically stressed mice across multiple stress paradigms and finds convergence with human psychiatric disorder gene expression patterns.

A Meta-Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models

This study performs a meta-analysis of rodent sleep deprivation transcriptome data to identify consistently differentially expressed genes across multiple studies.

Effect of Chronic Stress on Whole Blood Transcriptome: A Meta-Analysis of Publicly Available Datasets from Rodent Models

This paper performs a meta-analysis of three mouse datasets to identify stress-related gene expression changes in whole blood and links them to immune dysregulation and cellular aging.

A meta-analysis of the effects of early life stress on the prefrontal cortex transcriptome suggests long-term effects on myelin

This paper performs a meta-analysis of gene expression data from five datasets to identify long-term effects of early life stress on the prefrontal cortex, finding consistent downregulation of myelin-related genes and upregulation of genes related to Major Depressive Disorder.

Resource: A Curated Database of Brain-Related Functional Gene Sets (Brain.GMT)

The paper introduces Brain.GMT, a curated database of brain-related gene sets to improve interpretation of neuroscience studies by addressing the limitations of traditional gene ontology databases.

Adolescent environmental enrichment induces social resilience and alters neural gene expression in a selectively bred rodent model with anxious phenotype

This study shows that adolescent environmental enrichment improves social resilience and alters gene expression in genetically anxious rats, with differential effects on behavior and stress response.

Bioenergetic-Related Gene Expression in the Hippocampus Predicts Internalizing vs. Externalizing Behavior in a F2 Cross of Selectively-Bred Rats

The paper identifies gene expression patterns in the hippocampus of rats that predict internalizing and externalizing behaviors, linking them to genetic variation and biological processes.

Differences in microglia morphological profiles reflect divergent emotional temperaments: Insights from a selective breeding model

The paper investigates how microglia morphology differs between rat lines with distinct emotional temperaments and links these differences to baseline microglial reactivity.

Genetic liability for internalizing versus externalizing behavior manifests in the developing and adult hippocampus: Insight from a meta-analysis of transcriptional profiling studies in a selectively-bred rat model

This study identifies gene expression differences in the hippocampus of selectively-bred rats associated with internalizing and externalizing behaviors across development and adulthood.

INFERENCE OF CELL TYPE COMPOSITION FROM HUMAN BRAIN TRANSCRIPTOMIC DATASETS ILLUMINATES THE EFFECTS OF AGE, MANNER OF DEATH, DISSECTION, AND PSYCHIATRIC DIAGNOSIS

The paper predicts cell type composition in human brain transcriptomic datasets and shows how age, death manner, dissection, and psychiatric diagnosis affect cell type ratios.

Post-mortem molecular profiling of three psychiatric disorders

The paper compares transcriptomes and metabolomes of postmortem brain samples from schizophrenia, bipolar disorder, major depressive disorder, and controls to identify molecular differences and potential therapeutic targets.

Investigating circadian rhythmicity in pain sensitivity using a neural circuit model for spinal cord processing of pain

The paper develops a neural circuit model of spinal cord pain processing to investigate circadian rhythmicity in pain sensitivity and identifies dysregulated inhibition as a mechanism for phase shifts in neuropathic pain.

The Modulation of Pain by Circadian and Sleep-Dependent Processes: A Review of the Experimental Evidence

This paper reviews experimental evidence on how circadian rhythms and sleep affect pain sensitivity, informing mathematical models of pain-sleep interactions.

A Two-Process Model for Circadian and Sleep-dependent Modulation of Pain Sensitivity

The paper develops a mathematical model to predict how circadian rhythms and sleep behavior influence daily pain sensitivity variations.