Author

María Celeste Leal

Consejo Nacional de Investigaciones Científicas y TécnicasORCID 0000-0003-4263-4047Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:Drosophila· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Fernando Juan PitossiiD· 3 shared Brenda ErhardtiD· 2 shared Carina Cintia Ferrari· 2 shared María Isabel Farías· 2 shared Berenice Anabel Silva· 1 shared Christián HöchtiD· 1 shared Corina I. Garcia· 1 shared Diego Hernán Bodín· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersNeuroscience

Fernando Juan PitossiORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 8, 2026

"Plasma Membrane Calcium ATPase Downregulation in Dopaminergic Neurons Induces Presynaptic Dysfunction and Neuronal Vulnerability In Vivo and In Vitro"

Brenda Erhardt, Valentina Koltyk, Mauricio Ricardo Bruno Dellepiane…·María Celeste Leal

This study shows that PMCA downregulation in dopaminergic neurons causes calcium dysregulation, presynaptic dysfunction, and increased neuronal vulnerability in Drosophila without overt neurodegeneration.

DOI 10.64898/2026.04.30.721667

Drosophilaexperimental assay

𝕏 PostBluesky

NeurosciencePLoS ONEPeer-reviewedSep 26, 2023

Microglia-secreted TNF-α affects differentiation efficiency and viability of pluripotent stem cell-derived human dopaminergic precursors

Shirley D. Wenker, María Isabel Farías, Victoria Gradaschi…·Fernando Juan Pitossi

The paper investigates how microglia-secreted TNF-α affects the survival and differentiation of human dopaminergic precursors in a pro-inflammatory environment.

10 citations

humanrat

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NeurosciencebioRxivPreprintJul 25, 2019

Plasma Membrane Calcium Atpase downregulation in dopaminergic neurons alters cellular physiology and behavior in Drosophila melanogaster

Brenda Erhardt, María Celeste Leal, María Silvina Marcora…·Fernando Juan Pitossi

This study downregulates PMCA in dopaminergic neurons of Drosophila to model Parkinson's Disease, finding increased calcium, oxidative stress, locomotor changes, and lifespan reduction.

DOI 10.1101/714147

Drosophilaexperimental assay

𝕏 PostBluesky