Combination of mitochondrial tRNA and OXPHOS mutation reduces lifespan and physical condition in aged mice
Gesine Reichart, Johannes Mayer, Tursonjan Tokay, Falko Lange, Cindy Johne, Simone Baltrusch, Markus Tiedge, Georg Fuellen, Saleh Mohamed Ibrahim, Rüdiger Köhling
The paper shows that combining mitochondrial tRNA and OXPHOS mutations in mice leads to reduced lifespan and physical condition with age, but not with single mutations.
bioRxiv · Dec 13, 2017 · PreprintDevelopmental Biology