Rüdiger Köhling

This study compares short-term and long-term effects of deep brain stimulation on neuronal excitability and synaptic transmission in a dystonia animal model, revealing distinct mechanisms and implications for treatment optimization.

This study optimises intrastriatal deep brain stimulation by using a biophysical network model to align activity patterns with healthy states.

This study investigates how deep brain stimulation (DBS) affects cortico-striatal synaptic communication in dystonic hamsters, finding that DBS alters synaptic responses and inhibitory control differently in dystonic versus healthy tissue.

The paper compiles healthspan-related gene pathways in C. elegans and humans using literature review and molecular interaction data, identifying common themes like transcription and lipids.

This study shows that a mutation in mt-Nd2, a mitochondrial complex I gene, reduces lifespan and increases glucose intolerance in mice by affecting tryptophan levels and aging pathways.

The paper describes a method using pathway maps to analyze omics data, focusing on cellular senescence and its role in disease.

This study shows that high mitochondrial heteroplasmy in mice reduces lifespan and impairs glucose metabolism.

The paper shows that combining mitochondrial tRNA and OXPHOS mutations in mice leads to reduced lifespan and physical condition with age, but not with single mutations.