Joseph W. Schafer

The paper evaluates AF-cluster's performance on metamorphic proteins and finds random sequence sampling outperforms it, suggesting ColabFold-based methods as a better alternative.

The paper evaluates whether AlphaFold2 can predict alternative conformations of fold-switching proteins beyond its training data using a modified model trained on a limited dataset.

This study evaluates AlphaFold2's ability to predict fold-switching proteins and finds it has limited success in sampling multiple conformations and accurately assessing confidence metrics.

The paper shows that ColabFold can predict alternative protein structures without needing coevolutionary information from clustered MSAs, using only single sequences or sequence similarity.

The paper identifies coevolutionary signatures in fold-switching proteins and uses them to predict alternative protein conformations using AlphaFold2.