Devlina Chakravarty

The paper describes a protein fold switch in a bactericidal nanomachine that enables membrane puncture and bactericidal activity.

The paper evaluates AF-cluster's performance on metamorphic proteins and finds random sequence sampling outperforms it, suggesting ColabFold-based methods as a better alternative.

This study evaluates AlphaFold2's ability to predict fold-switching proteins and finds it has limited success in sampling multiple conformations and accurately assessing confidence metrics.

The paper shows that ColabFold can predict alternative protein structures without needing coevolutionary information from clustered MSAs, using only single sequences or sequence similarity.

The paper identifies an evolutionary pathway between two protein folds using statistical methods and structural models on bacterial response regulator proteins.

The paper evaluates AlphaFold2's performance on fold-switching proteins, finding it predicts one conformation accurately but misses others, despite high confidence scores.