Author

Joleen Masschelein

VIB-KU Leuven Center for MicrobiologyORCID 0000-0003-4366-3675Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Microbiology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:benchmarking· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1 Assay:metagenomics· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Lucas De VriezeiD· 2 shared Alex Quintero‐YanesiD· 1 shared Angus N. M. WeiriD· 1 shared Dries De RuysscheriD· 1 shared Emmanuel L. C. de los SantosiD· 1 shared Eric BreynaertiD· 1 shared Eveline LescrinieriD· 1 shared Ewoud VaneeckhauteiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersBioinformatics

Lucas De VriezeORCID

Author profile →

4 papers

Recent·Most cited

Charting the biosynthetic landscape of hybrid polyketide-nonribosomal peptide-specialized lipids

Fatima El Arnouki Belhaji, Dries De Ruysscher, Giel Vanreppelen, Laura-Lynn Huybrechts, Mohammad M. Alanjary, Mitja M. Zdouc, Emmanuel L. C. de los Santos, Joachim Demaerel, Ewoud Vaneeckhaute, Odessa Van Goethem, Hans Gerstmans, Eric Breynaert, Patrick Van Dijck, Marnix H. Medema, Angus N. M. Weir, , Joleen Masschelein

The paper identifies and characterizes new hybrid peptide-polyketide-specialized lipid biosynthesis pathways in bacteria, revealing novel metabolites with functional properties.

JACS Au · Jun 8, 2026Peer-reviewedMicrobiology

CAGEcleaner: reducing genomic redundancy in gene cluster mining

Lucas De Vrieze, Miguel Biltjes, Sofya Lukashevich, Kodai Tsurumi, Joleen Masschelein

CAGEcleaner reduces genomic redundancy in gene cluster hit sets to improve BGC discovery workflows by dereplicating genomes hosting hits.

Bioinformatics · Jun 24, 2025Peer-reviewedBioinformatics

Comparative pangenomics unveils distinct host adaptation levels and conserved biosynthetic potential in microbiome Clostridia

Lucas De Vrieze, Jan A Aerts, Joleen Masschelein

This study compares pangenomes of Clostridia to reveal differences in host adaptation and conserved biosynthetic potential across orders.

bioRxiv · Feb 12, 2025 · PreprintBioinformatics

Multiplexing bacteriocin synthesis to kill and prevent antimicrobial resistance

Alex Quintero‐Yanes, Kenny Petit, Hector Rodriguez‐Villalobos, Hanne Vande Capelle, Joleen Masschelein, Juan Borrero, Philippe Gabant

The paper develops bacteriocin cocktails using cell-free synthesis to target and eliminate antibiotic-resistant bacteria, demonstrating effectiveness in vivo.

bioRxiv · Sep 6, 2024 · PreprintSynthetic Biology