Philip K. McGuire

The paper examines the relationship between white matter microstructure, measured by fractional anisotropy, and transition to psychosis in individuals at clinical high risk, finding directionally consistent but small associations.

The paper examines longitudinal white matter changes in early psychosis using diffusion tensor imaging and finds no significant group differences or associations with symptom progression, but links antipsychotic medication dose to lower fractional anisotropy.

The paper examines cortical excitation-inhibition imbalance in psychosis using resting-state fMRI and EEG, finding reduced Hurst exponents and aperiodic spectral exponents associated with molecular pathways.

The paper identifies cellular and neurochemical signatures associated with cerebral blood flow alterations in schizophrenia and clinical high-risk states using combined neuroimaging and transcriptomic data.

This study examines brain morphometric deviations in individuals at clinical high-risk for psychosis and finds they largely overlap with healthy variation and are not strongly associated with symptom severity or conversion to psychosis.

This work develops normative models of brain growth and aging using neuroimaging data to quantify variability across disorders and improve case-control inferences.

The paper examines how genetic and epigenetic factors at AKT1 rs1130233 modulate THC-induced brain activation during fear processing in healthy males.

The paper identifies co-expression patterns between GABA receptor subunits and interneuron markers, linking them to in vivo PET radiotracer binding in human brain data.

The paper links reduced cortical morphometric similarity in psychosis to the expression of schizophrenia-related genes in specific brain regions.

This study finds that perinatal brain injury in very preterm humans is linked to reduced dopamine synthesis and hippocampal volume in adulthood.