Kenz Le Gouge

The paper identifies sex-specific differences in TCR selection during thymic development, showing female effector T cells have more autoimmunity-associated TCRs while female Tregs have fewer.

This study identifies Treg dysfunction as associated with OA-related pain through multi-omic analysis of peripheral blood from knee OA patients.

The paper benchmarks nine unsupervised methods for inferring TCR specificity using a curated database of 190,670 human TCRs, identifying method-specific strengths in retention, purity, and sensitivity.