Hélène Vantomme

The paper identifies a shared Treg dysfunction signature across rheumatic diseases, suggesting a therapeutic window of opportunity for Treg-targeted treatments.

The paper identifies sex-specific differences in TCR selection during thymic development, showing female effector T cells have more autoimmunity-associated TCRs while female Tregs have fewer.

This study identifies Treg dysfunction as associated with OA-related pain through multi-omic analysis of peripheral blood from knee OA patients.

The paper benchmarks nine unsupervised methods for inferring TCR specificity using a curated database of 190,670 human TCRs, identifying method-specific strengths in retention, purity, and sensitivity.

This study shows IL-1β signaling affects Tfh and Tfr cells in human lymphoid tissues, linking it to autoantibody production and autoimmune disease.