Cancer BiologyCancer Research CommunicationsPeer-reviewed
BRCA1 and BRCA2 germline mutations driven signaling pathway alterations are sufficient to initiate breast tumorigenesis by the PIK3CAH1047R oncogene.
Poornima Bhat‐Nakshatri, Aditi Sanjay Khatpe, Duojiao Chen…·Harikrishna Nakshatri
This paper compares single-cell transcriptomes of BRCA1/2 mutation carriers and non-carriers to show how these mutations alter signaling pathways and drive breast cancer development through PIK3CA mutations.