Sofía Granados-Aparici

DANEELpath is an open-source image analysis toolkit developed to study the effects of vitronectin and cilengitide in 3D-grown neuroblastoma cells using deep learning and spatial feature extraction.

This study evaluates the binding affinity and cell viability effects of natural compounds and cilengitide on HR-NB cells, finding Olax CHA shows superior antiproliferative effects and potential synergism with cilengitide.

The paper shows that SMAD4 deletion in granulosa cells reduces transzonal projections (TZPs) contacting oocytes, suggesting TGFβ signaling stabilizes soma-germline communication.