Kenneth H. Hu

Discovery of a Linked Constellation of Gene Expression Revealed by Local Editing of Fibroblasts in Tumors

The paper uses local gene editing in mouse tumor models to discover a novel fibroblast state and its impact on the tumor microenvironment.

Spatial immune hubs defined by conserved activated dendritic cells are remodeled by immunotherapy

The paper constructs an integrated atlas of tumor-infiltrating dendritic cells across species and immunotherapy conditions, revealing conserved activation states and spatial reorganization in response to therapy.

Macrophage-Dendritic Cell-T-Cell Tetrads Orchestrate Antitumor Immunity and Response to Checkpoint Blockade

The paper identifies tetrads as a multicellular immune unit that correlates with antitumor immunity and response to checkpoint blockade in mouse and human tumors.

Bhlhe40 Governs T Cell Effector Differentiation with Distinct Requirements in CD4 and CD8 T Cells for Anti-PD-1 and Anti-CTLA-4 Efficacy

This study identifies Bhlhe40 as a key regulator of T cell effector differentiation, showing distinct roles in CD4 and CD8 T cells for anti-PD-1 and anti-CTLA-4 therapies.

Space-Time Mapping Identifies Concerted Multicellular Patterns and Gene Programs in Healing Wounds and their Conservation in Cancers

The paper identifies space-time gene expression patterns in healing wounds and finds their conservation in tumors, revealing multicellular coordination and gene program activation.

ZipSeq : Barcoding for Real-time Mapping of Single Cell Transcriptomes

ZipSeq maps single-cell transcriptomes in real-time within intact tissues, revealing new gene expression patterns and differentiation trajectories in various biological contexts.