Kay C. Wiese

The paper introduces a pan-cell type chromatin state annotation that integrates all IHEC epigenomes using the epigenome-ssm method, avoiding cell type-specific annotations.

HyPlAs improves plasmid assembly from hybrid sequencing data by classifying short-read contigs as chromosomal or plasmidic, outperforming Plassembler on bacterial samples.

The paper develops a hybrid machine learning model, ChromeCRISPR, which outperforms existing models in predicting CRISPR/Cas9 on-target activity by combining CNN and RNN architectures.

SigTools provides visualization tools for genomic signals to aid in data exploration and interpretation, with case studies on histone modifications and novel chromatin features.