Morteza Abyadeh

This study shows that NPC1 deficiency causes genomic instability and immune activation linked to neurodegeneration and aging, and identifies Fingolimod as a potential treatment.

This study compares protein cargo differences in mesenchymal stem cell-derived extracellular vesicles isolated by three methods, finding method-specific impacts on proteome composition and biological function.

The paper investigates proteome and transcriptome changes in Alzheimer's disease brains and identifies a stem cell-derived extracellular vesicle subpopulation with therapeutic potential for mitochondrial proteostasis and inflammation.

The paper identifies a Niemann-Pick type C mouse model with accelerated brain aging as a novel model for Alzheimer's disease research by analyzing transcriptomic data from congenital diseases.

The paper identifies common molecular signatures between coronavirus infection and Alzheimer's disease to suggest potential therapeutic targets.

The paper investigates how knocking out nuclear-encoded mitochondrial genes in yeast affects lifespan, revealing shared mechanisms involving ribosomal proteins, actin dynamics, and proteasome function.