Author

Pei‐Chi Hou

University of VirginiaORCID 0000-0002-3709-5934Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1

Frequent Co-Authors

Yuh‐Hwa WangiD· 2 shared Aakrosh RataniD· 1 shared Alaattin KayaiD· 1 shared Anna R. Bartosik· 1 shared Bushra Mehkri· 1 shared Elizabeth Malaugh· 1 shared James P. Vaughn· 1 shared Jason NewtoniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

Yuh‐Hwa WangORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJul 13, 2026

NPC1 deficiency engages a lysosome - genome - immune program linked to neurodegeneration and cellular aging signatures

Morteza Abyadeh, Masoumeh Zarei‐Kheirabadi, Pei‐Chi Hou…·Alaattin Kaya

This study shows that NPC1 deficiency causes genomic instability and immune activation linked to neurodegeneration and aging, and identifies Fingolimod as a potential treatment.

DOI 10.64898/2026.07.12.738054

mouseC. elegans

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Molecular BiologyNucleic Acids ResearchPeer-reviewedJun 14, 2025

Loss of DHX36/G4R1, a G4 resolvase, drives genome instability and regulates innate immune gene expression in cancer cells

Anna R. Bartosik, Pei‐Chi Hou, Shangming Tang…·Yuh‐Hwa Wang

This study shows that loss of DHX36/G4R1 increases genome instability and innate immune gene expression in cancer cells, correlating with improved survival in B-cell acute lymphoblastic leukemia.

13 citationstop 5%

humanwhole-genome sequencing

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