PhysiologyNature Cardiovascular ResearchPeer-reviewed
Ablation of three major phospho-sites in RyR2 preserves the global adrenergic response but creates an arrhythmogenic substrate
Jingjing Zheng, Daniela Ponce‐Balbuena, Erick B. Ríos Pérez…·Francisco J. Alvarado
This study shows that ablating three key phospho-sites in RyR2 preserves adrenergic responses but increases arrhythmogenic risk by altering Ca2+ leak and promoting early afterdepolarizations.
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