Francisco J. Alvarado

This study shows that RyR2-mediated Ca2+ leak causes arrhythmias and progressive cardiomyopathy in rabbits, identifying RyR2 as a therapeutic target.

This study shows that adult mouse hearts maintain cardiac function despite significant RyR2 depletion through intrinsic ECC plasticity mechanisms.

This study identifies Rad and phospholamban as critical regulators of the adrenergic response and stress-induced arrhythmia through their role in calcium handling and cardiac function.

This study shows that ablating three key phospho-sites in RyR2 preserves adrenergic responses but increases arrhythmogenic risk by altering Ca2+ leak and promoting early afterdepolarizations.

The paper identifies and quantifies S-glutathionylation in ventricular myosin light chain 1 across human, swine, and mouse cardiac tissues using top-down proteomics.