Molecular BiologyCell ReportsPeer-reviewed
Negative autoregulation mitigates collateral RNase activity of repeat-targeting CRISPR-Cas13d in mammalian cells
Chase P. Kelley, Maja C. Haerle, Eric T. Wang
The paper investigates collateral RNase activity of Cas13d in mammalian cells and introduces GENO to mitigate it for repeat-targeting RNA therapies.
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