Richard Daneman

The paper identifies transcription factors that induce BBB properties in human pluripotent stem cell-derived endothelial cells through forward programming.

This study shows that beta-hydroxybutyrate (betaHB) improves neuronal Tau proteostasis and reduces Tau aggregation in tauopathy models, independent of its ketolysis for ATP production.

This study identifies dynamic fibroblast-immune interactions that regulate CNS wound healing and neuroinflammation after brain injury.

The paper analyzes the BBB glycocalyx using multi-omic approaches, revealing unique glycan composition and structural features, and their potential role in neuroinflammation.

This study shows that microglia drive diurnal variation in BBB permeability during inflammation, with increased BBB breakdown following evening LPS injection.

The paper investigates the role of microglia in maintaining blood-brain barrier properties in health and finds that microglia are not required, but PLX5622 treatment affects endothelial cholesterol metabolism.

The paper shows neuronal activity increases brain endothelial cholesterol synthesis and uptake, which inhibits arteriole dilation and acts as a negative feedback mechanism for neurovascular coupling.

The paper uses in vivo two-photon imaging to distinguish perivascular fibroblasts from mural cells in mouse cerebral cortex, revealing unique structural and distributional features.

The paper shows that astrocytes contribute to cerebral cavernous malformations (CCMs) through VEGF production driven by endothelial NO, highlighting non-cell-autonomous mechanisms.

The paper identifies LY6A as a novel receptor for AAV-PHP.B vectors, enabling efficient gene delivery across the blood-brain barrier in mice.

The paper generates human pluripotent stem cell-derived brain pericyte-like cells that induce blood-brain barrier properties in endothelial cells and form an isogenic NVU model.

The paper shows BBB efflux transporters regulate endogenous steroids and behaviors, and drug interactions with these transporters cause behavioral side effects.