Microglia are not required for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism
Caterina P. Profaci, Sean S. Harvey, Kaja Bajc, Tony Z Zhang, Danielle A Jeffrey, Alexander Z Zhang, Kelsey Marie Nemec, Hayk Davtyan, Carleigh A. O’Brien, Gabriel L. McKinsey, Aaron J. Longworth, Timothy P McMullen, Joia Kai Capocchi, Jessica G Gonzalez, Devon A. Lawson, , Richard Daneman
The paper investigates the role of microglia in maintaining blood-brain barrier properties in health and finds that microglia are not required, but PLX5622 treatment affects endothelial cholesterol metabolism.
Neuron · Aug 13, 2024Peer-reviewedNeuroscience