Lili Niu

The paper introduces a novel hybrid mass spectrometer, Stellar MS, enabling rapid and sensitive clinical biomarker validation using 15N labeled proteins.

This study identifies genetic determinants of plasma protein levels in children and adolescents using MS-based proteomics, revealing extensive genetic impacts that persist into adulthood.

The paper identifies non-linear genetic regulation of plasma proteins using a deep learning method, finding dominance and epistasis effects in large cohorts.

This paper introduces a deep learning method for imputing missing values in label-free quantitative proteomics data and shows its effectiveness in identifying differentially abundant proteins in alcohol-related liver disease.

The paper quantifies the human liver proteome at cell-type resolution across multiple conditions, revealing proteome changes in disease states and providing a web-based resource for exploration.

The Clinical Knowledge Graph (CKG) links over 16 million nodes and 220 million relationships with statistical and machine learning workflows to accelerate proteomics data analysis and clinical biomarker interpretation.