Microglial Lag3 Drives α-Synuclein--induced Neurotoxic Activated (A1) Astrocytes and Neurodegeneration
Xiuli Yang, Ramhari Kumbhar, Bo Am Seo, Shinwon Ha, Jared T. Hinkle, Ning Wang, Shuya Li, Lili Niu, Haiqing Liu, Nicolas Stanciu, Rong Chen, Yasuyoshi Kimura, Enquan Xu, Fangyi Cheng, Sung-Ung Kang, , Xiaobo Mao
This study identifies microglial Lag3 as a key receptor linking extracellular α-synuclein PFF recognition to neurotoxic astrocyte conversion and dopaminergic neurodegeneration.
bioRxiv · Jan 6, 2026 · PreprintNeuroscience