NOD2 activation reprograms infiltrating inflammatory monocytes in the Zika virus infected CNS to maintain neural correlates of learning and memory
Jeremy D. Hill, Alice H.W. Dong, Joshua Liu, Marina Diniz Barbezani, Tallulah S. Andrews, Robyn S Klein
This study shows that NOD2 activation with MDP during ZIKV infection shifts monocytes to an anti-inflammatory state, preserving synapses and cognitive function in the hippocampus.
bioRxiv · May 21, 2026 · PreprintImmunology