This study improves understanding of Mycobacterium tuberculosis lineage 5 diversity and phylogeography using new genomic data and a novel bioinformatics pipeline.

bioRxiv · Nov 21, 2022 · PreprintGenomics

Connection between two historical tuberculosis outbreak sites in Japan, Honshu, due to a new ancestral L2 sublineage

Christophe Guyeux, Gaëtan Senelle, Guislaine Refrégier, Florence Bretelle‐Establet, Emmanuelle Cambau, Christophe Sola

The paper identifies a new ancestral L2 sublineage of Mycobacterium tuberculosis in Japan, linking historical tuberculosis outbreaks through genetic analysis.

Epidemiology and Infection · Jan 1, 2022Peer-reviewedGenetic & Genomic Medicine

Local adaptation in populations of Mycobacterium tuberculosis endemic to the Indian Ocean Rim

Fabrizio Menardo, Liliana K. Rutaihwa, Michaela Zwyer, Sònia Borrell, Iñaki Comas, Emilyn Costa Conceição, Mireia Coscollá, Helen Suzanne Cox, Moses Lutaakome Joloba, Horng-Yunn Dou, Julia Feldmann, Lukas Fenner, Janet Fyfe, Qian Gao, Darı́o Garcı́a de Viedma, , Sébastien Gagneux

The paper analyzes whole genome sequences of Mycobacterium tuberculosis lineages L1 and L3 to show South Asia's role in their dispersion and identify local adaptation at the esxH locus.

F1000Research · Feb 1, 2021Peer-reviewedGenomics

Exhaustive reconstruction of the CRISPR locus in Mycobacterium tuberculosis complex using short reads

Christophe Guyeux, Christophe Sola, Guislaine Refrégier

The paper reconstructs CRISPR loci in Mycobacterium tuberculosis complex using short reads, revealing errors in existing reconstructions and new structural features.

bioRxiv · Nov 16, 2019 · PreprintGenomics