Molecular BiologybioRxivPreprint
Posttranscriptional activity of the eukaryotic translation initiation factoreIF4E contributes to HoxA9-driven leukemogenesis
Fang Zhou, Biljana Čuljković, Christian Bach…·Daniel Geoffrey Tenen
This study shows that disrupting the interaction between HoxA9 and eIF4E delays AML onset and reduces disease penetrance, suggesting eIF4E as a therapeutic target in HoxA9-driven leukemia.
DOI 10.1101/2025.02.10.637540