Daniel Geoffrey Tenen

The paper shows that oncogene-imposed dosage constraints can lead to mutations resembling tumor suppressor loss, which are essential in APL.

This study identifies CEBPA-N-AML as having enhanced engraftment and defines a novel LSC signature in CEBPA-N-AML.

This study identifies the mechanism by which AW1-51, a small activating RNA, promotes DNA demethylation and reactivation of the CEBPA gene in cancer.

This paper discovers and characterizes SH6, a small molecule degrader of ZBTB7A that increases fetal hemoglobin expression in erythroid cells and shows therapeutic potential for β-hemoglobinopathies.

This study identifies a PU.1/LOUP feed-forward regulatory loop that promotes monocyte/macrophage differentiation and innate immune functions through enhancer RNA-mediated mechanisms.

This study shows that disrupting the interaction between HoxA9 and eIF4E delays AML onset and reduces disease penetrance, suggesting eIF4E as a therapeutic target in HoxA9-driven leukemia.

The paper demonstrates that disrupting super-silencers via EZH2 and REST inhibition reduces chromatin interactions and cancer growth.

The paper identifies PU.1 cis-regulatory elements in human blood cell lineages and shows how chromatin structure and 3D architecture influence their function as enhancers or silencers.

This paper demonstrates the use of eR1-CreERT2 transgenic mice to target and study hematopoietic stem cells (HSCs) across developmental stages, revealing stage-specific phenotypes and disease outcomes.

The paper identifies LEVER RNA as a regulator of ε-globin expression by inhibiting PRC2-mediated H3K27 methylation and disrupting promoter-LCR interactions.

The paper shows that cell cycle-specific long noncoding RNAs regulate the establishment and recycling of the acetylated histone H2A.Z epigenetic mark.

The paper identifies S-phase RNAs that anchor ORC1 to H2A.Z, enabling DNA replication initiation and revealing an RNA-mediated mechanism for replication origin formation.

ChIP-AP is a ChIP-Seq analysis pipeline that integrates multiple peak callers to improve peak detection confidence and comprehensiveness.

CRISPR-DiR induces locus-specific demethylation and chromatin remodeling to reactivate the p16 gene.

This study shows that SALL4 can be induced in cancer cells to make them dependent on it, enabling targeted therapy with drugs like DAC and ENT.

This study shows TIP60 acetylates H2AZ, affecting DNA repair gene expression and doxorubicin sensitivity through RAD51 transcription.

NanoVar accurately detects structural variants using low-depth Nanopore sequencing, achieving high F1 score in simulated data and uncovering normal alleles in patient samples.

FLARE is a framework for fast and automatic detection of rare cell populations in flow cytometry data using hierarchical Bayesian models and parallel computation.

The paper identifies the DNA binding domain and sequence of SALL4, discovers its target genes in liver cancer cells, and reveals its mechanism of gene regulation.

This study identifies ADAR1's interaction with transcriptional byproducts using integrated sequencing data, revealing its role in RNA processing and debris clearance.