Cancer BiologybioRxivPreprint
Basic region variants of the MAX b-HLH-LZ preferentially form heterodimers with the MYC b-HLH-LZ to bind the E-box rather than binding as homodimers.
Vincent Roy, Martin Montagne, Pierre Lavigne
This study examines how specific MAX variants with missense mutations in the basic region affect their ability to form heterodimers with MYC and bind E-Box DNA, suggesting a potential tumor suppressor role for MAX homodimers.
DOI 10.64898/2026.04.01.715400