Atsushi Kumanogoh

This study identifies Sema4A as an extrinsic factor that protects myeloid-biased HSCs from inflammatory stress, preserving functional diversity in the hematopoietic stem cell pool.

This study shows that downregulation of Sema4A in keratinocytes is associated with non-lesional psoriasis features and that Sema4A regulates skin homeostasis and inflammation.

The paper introduces scLinaX, a method to quantify X chromosome inactivation escape using scRNA-seq, revealing heterogeneity across cell types and tissues.

This study conducts a trans-ancestry GWAS of rheumatoid arthritis, identifying 124 loci, 34 novel, and shows improved polygenic risk score performance across populations.