Author

Le Qi

University of California, Los AngelesORCID 0000-0003-4832-2271Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:scRNA-seq· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Daniel H. GeschwindiD· 3 shared Alison GoateiD· 2 shared Brigitte L. ArduiniiD· 2 shared Celeste M M. KarchiD· 2 shared Kathryn R. BowlesiD· 2 shared Sally TempleiD· 2 shared Steven Lotz· 2 shared Susan M. BordeniD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersGenomics

Daniel H. GeschwindORCID

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3 papers

Recent·Most cited

GenomicsbioRxivPreprintApr 30, 2026

Multiomic Profiling of 85 iPSC Lines from Familial Dementia Reveals Cellular Diversity and Regulators of Organoid Development

Le Qi, Taylor B. Bertucci, Susan M. Borden…·Daniel H. Geschwind

The paper characterizes 85 MAPT mutation-bearing iPSC lines using multiomic approaches, revealing cellular diversity and factors influencing organoid development.

DOI 10.64898/2026.04.29.721747

humanwhole-genome sequencing

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GenomicsSciencePeer-reviewedApr 23, 2026

A single cell multi-omic analysis identifies molecular and gene-regulatory mechanisms dysregulated in the developing Down syndrome neocortex

Celine K. Vuong, Alexis Weber, Patrick Seong…·Luis de la Torre-Ubieta

This study uses single-nucleus multi-omics to analyze the developing Down syndrome neocortex, identifying dysregulated molecular and gene-regulatory mechanisms affecting neurogenesis and cell specification.

13 citationstop 1%

humanscRNA-seq

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NeurosciencebioRxivPreprintJul 11, 2023

Integrated Manufacturing Platform for Cortical Organoids Reveals Early Phosphatase and Prefoldin Dysregulation in MAPT V337M Neurons

Taylor B. Bertucci, Kathryn R. Bowles, Steven Lotz…·Sally Temple

The paper develops a scalable cortical organoid platform with quality control metrics and identifies early dysregulation of phosphatase and prefoldin genes in FTD-tau neurons.

19 citations

humanscRNA-seq

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