William W. Kwok

This paper introduces a DNA-barcode labelled MHCII multimer method to detect antigen-specific CD4 T cells across large epitope libraries and identifies 12 novel HCV epitopes.

This study identifies the transcriptional profile of circulating autoreactive CD4 T cells in autoimmune liver diseases and shows their functional relationship to liver-specific pathogenic clones.

T-REX identifies rare and common immune cell changes in COVID-19, rhinovirus infection, and cancer therapy using unsupervised machine learning.

The paper develops a systems-based approach to classify T-cell responses using transcriptome data from PBMCs stimulated with peptides, identifying new molecular patterns and transcription factors involved in antigen-specific responses.