Author

Manuela Leal da Silva

Universidade Federal do Rio de JaneiroORCID 0000-0003-4844-7138Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:protein sequence· 1 Assay:structural biology· 1

Frequent Co-Authors

Ana Carolina Silva BullaiD· 1 shared Rafael C. BernardiiD· 1 shared Raissa S. L. Rosa· 1 shared Raissa Santos de Lima RosaiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 2 mutual co-author links

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1 shared paperBioinformatics

Ana Carolina Silva BullaORCID

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2 papers

Recent·Most cited

BiochemistryBiochemistryPeer-reviewedMar 28, 2025

Atomistic Insights into gp82 Binding: A Microsecond, Million-Atom Exploration of Trypanosoma cruzi Host-Cell Invasion

Raissa S. L. Rosa, Manuela Leal da Silva, Rafael C. Bernardi

This study uses high-resolution computational modeling to uncover new molecular interactions between T. cruzi gp82 and LAMP2, revealing cooperative motions critical for host-cell invasion.

2 citations

humanmouse

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BioinformaticsbioRxivPreprintDec 7, 2023

Functional annotation hypothetical proteins: a world to be explored in drug development in Trypanosomatids

Raissa Santos de Lima Rosa, Ana Carolina Silva Bulla, Manuela Leal da Silva

The paper predicts functional domains of hypothetical proteins in Trypanosomatids to identify potential drug targets, finding three promising domains with conservation and multi-species impact.

DOI 10.1101/2023.12.07.570673

humanprotein sequence

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