Jenna E. Gallegos

Securing the exchange of synthetic genetic constructs using digital signatures

The paper demonstrates using digital signatures and encryption to secure synthetic genetic constructs by verifying authorship and integrity from sequencing data without a reference sequence.

Rapid, robust plasmid verification by de novo assembly of short sequencing reads

The paper develops a fast, open-source pipeline for plasmid sequence verification using de novo assembly of Illumina reads, demonstrating its ability to detect contaminating sequences.

Genetic interactions derived from high-throughput phenotyping of 7,350 yeast cell cycle mutants

The paper quantitatively estimates genetic interactions between 36 yeast cell-cycle genes using high-throughput phenotyping of 7,350 mutants and refines a mathematical cell cycle model.

Challenges and opportunities for strain verification by whole-genome sequencing

The paper demonstrates the need for whole-genome sequencing to verify laboratory strains by identifying unexpected mutations in yeast segregants and highlights challenges with current bioinformatics tools.

Intron-mediated enhancement is not limited to introns

The paper shows that intron-mediated enhancement can occur outside of introns and is mediated by specific sequences, not requiring splicing.

Intron-driven gene expression in the absence of a core promoter in Arabidopsis thaliana

The paper investigates intron-mediated enhancement in Arabidopsis thaliana, showing that certain introns can drive gene expression independently of core promoters and alter transcription start sites.