Jean Peccoud

The paper introduces a model explaining the transcriptional gradient in NNSVs through polymerase parameters, enabling genotype-based prediction of transcriptional behavior.

This study shows that using a single plasmid for co-transfection is more efficient and results in tighter gene expression correlation than using multiple plasmids.

The paper introduces self-documenting plasmids that encode their own information in DNA, enabling verification without prior knowledge of the plasmid identity.

The paper evaluates sequencing strategies for accurate plasmid assembly, finding that hybrid approaches provide the most reliable results while highlighting challenges in GC-rich and repetitive regions.

This paper develops a stochastic model of VSV replication to study how mutations affect virion production and intercellular variability.

The paper analyzes the reproducibility of experimental workflows by structuring data and applying statistical tests to identify factors affecting variation in plasmid purification and cell culture processes.

The paper demonstrates using digital signatures and encryption to secure synthetic genetic constructs by verifying authorship and integrity from sequencing data without a reference sequence.

The paper develops a fast, open-source pipeline for plasmid sequence verification using de novo assembly of Illumina reads, demonstrating its ability to detect contaminating sequences.

The paper quantitatively estimates genetic interactions between 36 yeast cell-cycle genes using high-throughput phenotyping of 7,350 mutants and refines a mathematical cell cycle model.

The paper demonstrates the need for whole-genome sequencing to verify laboratory strains by identifying unexpected mutations in yeast segregants and highlights challenges with current bioinformatics tools.

This paper develops a hybrid stochastic model to study noise effects on budding yeast cell cycle control, achieving efficient simulations matching experimental data.

The paper presents a stochastic model to study how kinase and phosphatase activities affect error correction and spindle assembly checkpoint signaling in budding yeast.